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Short Biography

I am Docent at the Faculty of Medicine in Umeå university. Previous to that I gained international experience during two postodctoral stays. The first was at the Institut Pasteur in Paris thanks to an EMBO fellowship, and I did a second postdoctoral stay at the Institute for Molecular Pathology in Vienna.

My doctoral work was perforrmed at the International Max Planck Research School & University of Technology Dresden,  in Germany.

I obtained my University edication (Licenciatura) at the Universidad Nacional Autónoma de México (UNAM) in Mexico City.


Sharma A., Aden R.O., Puhar A., Cisneros D.A. (2023). CRISPR-Cas guided mutagenesis of chromosome and virulence plasmid in Shigella flexneri by cytosine base editing. mSystems. 8.1:e01045-22. Open access link

Tadala L., Langenbach D., Dannborg M., Cervantes-Rivera R., Sharma A., Vieth K., Rieckmann L., Wanders M., Cisneros D.A., Puhar A., (2022). Infection-induced membrane ruffling initiates danger and immune signaling via the mechanosensor PIEZO1. Cell Reports. 40:111173 Open acces link

Graffeuil, A., Guerrero‑Castro, J., Assefa A., Uhlin, B.E. and Cisneros DA (2022). Polar mutagenesis of polycistronic bacterial transcriptional units using Cas12a. Microbial Cell Factories, 21:139. Open access  link

Hagberg A, Rzhepishevska O, Semenets A, Cisneros DA, Ramstedt M (2020). Surface analysis of bacterial systems using cryo‐X‐ray photoelectron spectroscopy. Surface and Interface Analysis, 52(12):792-801

Morales C., Ruiz-Torres M., Rodriguez-Acebes S., Lafarga V., Rodríguez-Corsino M., Megías D., Cisneros D.A., Peters J.M., Méndez J., Losada A (2020). PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection. Journal of Biological Chemistry, 295(1):146-57.

Muhar, M., Ebert, A., Neumann, T., Umkehrer, C., Jude, J., Wieshofer, C., Rescheneder, P., Lipp, J.J., Herzog, V.A., Reichholf, B., Cisneros, D.A. Hoffmann, T., Schlapansky, M.F. Bhat, P., von Haeseler, A., Köcher, T., Obenauf, A.C., Johannes Popow, J., Ameres, S.L., Zuber J., (2018) SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis. Science , 360(6390), 800-805.


*Wutz G., *Várnai C., *Nagasaka K. , *Cisneros D.A., Stocsits R.R., Tang W., Schoenfelder S.,

Jessberger G., Muhar M., Hossain M.J., Walther N., Koch B., Kueblbeck M., Ellenberg J., Zuber J., Fraser P., Peters J.M (2017) . Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins. EMBO J. 36(24), 3573-3599.


  • Comment in: Haarhuis J.H.I. & Rowland B.D. (2017) ‘Cohesin: building loops, but not compartments’ EMBO J. 36(24), pp. 3549-3551


Ladurner, R., Kreidl, E., Ivanov, M. P., Ekker, H., Idarraga-Amado, M. H., Busslinger, G. A., Wutz, G., Cisneros, D. A. and Peters, J. M. (2016) 'Sororin actively maintains sister chromatid cohesion', EMBO J. , 35(6), pp. 635-653.


Davidson, I. F., Goetz, D., Zaczek, M. P., Molodtsov, M. I., in't Veld, P. J. H., Weissmann, F., Litos, G., Cisneros, D. A. , Ocampo-Hafalla, M., Ladurner, R., Uhlmann, F., Vaziri, A. and Peters, J. M. (2016) 'Rapid movement and transcriptional re-localization of human cohesin on DNA', EMBO J. , 35(24), pp. 2671-2685.


Amorim, G. C., Cisneros, D. A. , Delepierre, M., Francetic, O. and Izadi-Pruneyre, N. (2014) 'H-1, N-15 and C-13 resonance assignments of PpdD, a type IV pilin from enterohemorrhagic Escherichia coli ', Biomolecular NMR Assignments , 8(1), pp. 43-46.


Tedeschi, A., Wutz, G., Huet, S., Jaritz, M., Wuensche, A., Schirghuber, E., Davidson, I. F., Tang, W., Cisneros, D. A. , Bhaskara, V., Nishiyama, T., Vaziri, A., Wutz, A., Ellenberg, J. and Peters, J. M. (2013) 'Wapl is an essential regulator of chromatin structure and chromosome segregation', Nature , 501(7468), pp. 564-568.


Campos, M., Cisneros, D. A. , Nivaskumar, M. and Francetic, O. (2013) 'The type II secretion system - a dynamic fiber assembly nanomachine', Research in Microbiology , 164(6), pp. 545-555.


#Cisneros, D. A. , Pehau-Arnaudet, G. and #Francetic, O. (2012) 'Heterologous assembly of type IV pili by a type II secretion system reveals the role of minor pilins in assembly initiation', Molecular Microbiology , 86(4), pp. 805-818. #SHARED CORRESPONDING AUTHOR.


  • Comment in: Burrows, L. L. (2012). Prime time for minor subunits of the type II secretion and type IV pilus systems. Molecular microbiology , 86 (4), pp. 765-769.


#Cisneros, D. A. , Bond, P. J., Pugsley, A. P., Campos, M. and #Francetic, O. (2012a) 'Minor

pseudopilin self-assembly primes type II secretion pseudopilus elongation', EMBO J. , 31(4), pp.



Campos, M., Nilges, M., Cisneros, D. A. and Francetic, O. (2010) 'Detailed structural and assembly model of the type II secretion pilus from sparse data', PNAS , 107(29), pp. 13081-13086.


Tellez, L. A., Blancas-Mejia, L. M., Carrillo-Nava, E., Mendoza-Hernandez, G., Cisneros, D. A. and Fernandez-Velasco, D. A. (2008) 'Thermal Unfolding of Triosephosphate Isomerase from Entamoeba histolytica : Dimer Dissociation Leads to Extensive Unfolding', Biochemistry , 47(44), pp. 11665-11673.


Cisneros, D. A. , Oberbarnscheidt, L., Pannier, A., Klare, J. P., Helenius, J., Engelhard, M., Oesterhelt, F. and Muller, D. J. (2008) 'Transducer binding establishes localized interactions to tune sensory rhodopsin II', S tructure , 16(8), pp. 1206-1213.


  • Comment in: Hoff, W. D., & Spudich, J. L. (2008) . Single-Molecule Tour de Force: Teasing Apart a Signaling Complex. Structure , 16 (8), pp 1149-1150.


Taubenberger, A., Cisneros, D. A. , Friedrichs, J., Puech, P. H., Muller, D. J. and Franz, C. M. (2007) 'Revealing early steps of alpha(2)beta(1) integrin-mediated adhesion to collagen type I by using single-cell force spectroscopy', Molecular Biology of the Cell , 18(5), pp. 1634-1644.


Shah, D. S., Thomas, M. B., Phillips, S., Cisneros, D. A. , Le Brun, A. P., Holt, S. A. and Lakey, J. H. (2007) 'Self-assembling layers created by membrane proteins on gold', Biochemical Society

Transactions , 35, pp. 522-526.

Preiner, J., Janovjak, H., Rankl, C., Knaus, H., Cisneros, D. A. , Kedrov, A., Kienberger, F., Muller, D. J. and Hinterdorfer, P. (2007) 'Free energy of membrane protein unfolding derived from single-molecule force measurements', Biophysical Journal , 93(3), pp. 930-937.


Cisneros, D. A. , Friedrichs, J., Taubenberger, A., Franz, C. M. and Muller, D. J. (2007) 'Creating

ultrathin nanoscopic collagen matrices for biological and biotechnological applications', Small, 3(6), pp. 956-963.


Janovjak, H., Kedrov, A., Cisneros, D. A. , Sapra, K. T., Struckmeier, J. and Muller, D. J. (2006)

'Imaging and detecting molecular interactions of single transmembrane proteins', Neurobiology of Aging , 27(4), pp. 546-561.


Cisneros, D. A. , Muller, D. J., Daud, S. M. and Lakey, J. H. (2006) 'An approach to prepare membrane proteins for single-molecule imaging', Angewandte Chemie-International Edition , 45(20), pp. 3252-3256.


Cisneros, D. A. , Hung, C., Franz, C. A. and Muller, D. J. (2006) 'Observing growth steps of collagen self-assembly by time-lapse high-resolution atomic force microscopy', Journal of Structural Biology , 154(3), pp. 232-245.


Poole, K., Khairy, K., Friedrichs, J., Franz, C., Cisneros, D. A. , Howard, J. and Mueller, D. J. (2005) 'Molecular-scale topographic cues induce the orientation and directional movement of fibroblasts on two-dimensional collagen surfaces', Journal of Molecular Biology , 349(2), pp. 380-386.

Cisneros, D. A. , Oesterhelt, D. and Muller, D. J. (2005) 'Probing origins of molecular interactions stabilizing the membrane proteins halorhodopsin and bacteriorhodopsin', Structure , 13(2), pp.



  • Comment in: Chin, G. ‘Editor’s Choice: Deconstructing Membrane proteins’, Science , 307(5713), p. 1171.


*Cisneros, D. A., *Montero-Moran, G. M., Lara-Gonzalez, S. and Calcagno, M. L. (2004) 'Inversion of the allosteric response of Escherichia coli glucosamine-6-P deaminase to N-acetylglucosamine 6-P, by single amino acid replacements', Archives of Biochemistry and Biophysics , 421(1), pp. 77-84.



Pérez- Armendariz, Lamoyi, E., Mason, J. I., Cisneros-Armas, D. , Luu- The, V., & Bravo Moreno, J. (2004) ‘Developmental regulation of connexin 43 expression in fetal mouse testicular cells’, The Anatomical Record , 264 (3), pp. 237-246.

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